Banca de DEFESA: Edmilson Leal Bastos de Moura

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : Edmilson Leal Bastos de Moura
DATE: 24/10/2025
TIME: 14:00
LOCAL: Sala 3 - Faculdade de Ciências da Saúde - FS - UnB
TITLE:

“Presepsin as a diagnostic and prognostic biomarker of sepsis-associated acute kidney injury: a scoping review of clinical evidence”

KEY WORDS:

“presepsin; sCD14-ST; acute kidney injury; renal injury; sepsis; septic shock; sepsis associated acute kidney injury.”

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

“Introduction: Sepsis is a complex clinical syndrome associated with high morbidity and mortality and organ dysfunction, most notably acute kidney injury. Early recognition determines crucial clinical decisions for septic individuals. This rapid diagnosis depends on the accuracy of biomarkers in the context of coexisting renal dysfunction. In this context, the value of presepsin has been investigated and contested for a decade, with no definitive answers. Objective: This scoping review aims to evaluate the existing evidence regarding the accuracy of presepsin as a diagnostic and prognostic biomarker for sepsis-associated acute kidney injury (SA-AKI). Method: A search for references in databases (PubMed/Medline, Web of Science, Embase, and Scopus) was performed, following the PRISMA-ScR guidelines. 130 articles were retrieved, which were then subjected to sequential selection by three independent readers. Results: Nine publications were selected for fulltext reading, and descriptive analysis was performed, with narrative synthesis. Conclusion: Presepsin has good diagnostic and prognostic accuracy in patients with SA-AKI; however, it requires specific threshold values, the determination of which still depends on new controlled and randomized studies.”

COMMITTEE MEMBERS:
Externo à Instituição - HUGO DE LUCA CORRÊA - UCB
Presidente - ***.342.796-** - RINALDO WELLERSON PEREIRA - UnB
Externo à Instituição - ROBERT EDWARD POGUE - UCB
Interna - 3342495 - TAIA MARIA BERTO REZENDE
Externo à Instituição - THIAGO DOS SANTOS ROSA - UCB