Banca de DEFESA: Lorena Roberta de Souza Mendes Kawamura

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : Lorena Roberta de Souza Mendes Kawamura
DATE: 12/12/2023
TIME: 09:00
LOCAL: Plataforma Microsoft Teams
TITLE:

CINERRADIOGRAPHIC ANALYSIS OF APNEA IN AN EXPERIMENTAL MODEL AND PERCEPTION OF HUMAN INDIVIDUALS ABOUT APNEA IN PARKINSON'S DISEASE

 

KEY WORDS:

Parkinson's disease; Apnea; Swallow apnea

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Introduction. Parkinson's disease has symptoms and motor signs that are well elucidated in the literature, however non-motor symptoms remain little studied. Among these symptoms, apnea deserves to be highlighted. Goals. The objective of this research was to analyze apnea in Parkinson's Disease in different conditions. Materials and methods. The study consists of a stage carried out by an experimental model and another stage by humans. In the stage with animals, apnea was analyzed; basal breathing, under the influence of stress, when swallowing. The animals used were C57BL/6J mice. To analyze baseline breathing, three groups were analyzed: the control group (n=18), the early stage Parkinson's group (n=9) and the advanced stage Parkinson's group (n=9). To analyze the influence of stress on apnea, the control group (n=18) and advanced stage Parkinson's (n=9). To analyze swallowing apnea and swallowing, the control group (n=8) and early Parkinson's (n=15). The experimental groups were induced to mimic characteristics of Parkinson's disease through neurosurgery and application of 6-hydroxydopamine to the striatum. The animals were subjected to behavioral tests and subsequently analyzed individually in the cineradiography device. Important measurements were made using the KINOVEA software. The statistical tests used were the UMann-Whitney, Friedman and the Wilcoxon test. Descriptive statistics were also used. In the human stage, individuals with the pathology (n=100) responded to a questionnaire to verify their perception of the presence of apnea and percentages were used to analyze the results. Results. Apnea is more frequent in the experimental groups, especially in the advanced Parkinson's group. After the advanced Parkinson's group was subjected to stress, it was clear that the level of stress affects the frequency of spontaneous apnea. Regarding swallowing apnea in the early Parkinson group, not all animals performed apnea during swallowing. Conclusion: The severity of the pathology affects the frequency of apnea in basal breathing, physical stress evidences spontaneous apnea, and lack of synchrony between breathing and apnea in the swallowing process has been present since the beginning of the disease.

COMMITTEE MEMBERS:
Interno - 1764941 - DIEGO MADUREIRA DE OLIVEIRA
Presidente - 1646309 - JORGE LUIS LOPES ZEREDO
Externa à Instituição - MARISTELA SAYURI INOUE-ARAI
Interno - 2376346 - OTAVIO DE TOLEDO NOBREGA
Externa à Instituição - RUTH LOSADA DE MENEZES - UFG