Banca de DEFESA: LARISSA DI CARVALHO MELO E SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : LARISSA DI CARVALHO MELO E SILVA
DATE: 01/11/2024
TIME: 14:00
LOCAL: Plataforma Virtual - Microsoft Teams
TITLE:

Current trends and available evidence on low-level laser therapy for osteoradionecrosis: A scoping review

KEY WORDS:

Osteoradionecrosis; Laser therapy; Photobiomodulation therapy; Photodynamic Therapy; LowLevel Light Therapy; LLLT; Scoping review.

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Osteoradionecrosis (ORN) is a complication of radiotherapy for head and neck tumors, characterized by pain, infection, and deterioration in quality of life. Although Low-Level Laser Therapy (LLLT) and antimicrobial photodynamic therapy (aPDT) have shown efficacy in treating ORN by accelerating healing and controlling inflammation, there are still no standardized protocols for their use. The lack of clear treatment parameters prevents definitive conclusions about their clinical effectiveness. This scoping review explored current trends and available evidence on LLLT in the management and prevention of osteoradionecrosis, highlighting gaps in current research. The search strategy was conducted in MEDLINE/PubMed, EMBASE, Web of Science, and grey literature on January 15, 2024, without language or time restrictions. In total, 19 studies were included. The application of LLLT protocols was 58% for therapeutic use, 21% for preventive use, and 21% for a combination of both. Regarding the use of antimicrobial photodynamic therapy (aPDT), 41% of the studies employed this technique, which utilized methylene blue as the photosensitizer. For treatments associated with photobiomodulation, 57% reported pharmacological treatment, 29% surgical treatment, 11% prescribed chlorhexidine mouthwashes, and 4% other therapies. In vivo studies used diode lasers emitting low incident power densities in the near-infrared wavelength (67%) at 780 to 904 nm. In comparison, case reports also used diode lasers emitting low incident power densities in the red and near-infrared wavelength (64%) at 660 to 904 nm. The continuous emission mode was utilized in 83% of in vivo studies and 17% of the case reports. None of the studies included in this review reported all laser parameters. LLLT shows promise for therapeutic and preventive purposes. However, incomplete data on laser parameters makes it difficult to establish standardized treatment protocols. The studies exhibited significant heterogeneity in study design, laser parameters, administration protocols, and interventions in the control groups. Therefore, more studies with homogeneous methodologies are needed to enhance and evaluate the effectiveness of the LLLT in osteoradionecrosis.

COMMITTEE MEMBERS:
Externa à Instituição - AMANDA GOMES DE MENESES - UDF
Externo ao Programa - 3437282 - ANDRE FERREIRA LEITE - nullPresidente - 1278451 - ELIETE NEVES DA SILVA GUERRA
Interna - 2528668 - PAULA ELAINE DINIZ DOS REIS