Banca de QUALIFICAÇÃO: SAMYRA MARA COELHO CAXITO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : SAMYRA MARA COELHO CAXITO
DATE: 27/11/2025
TIME: 14:00
LOCAL: ID da Reunião: 262 164 053 726 65 / Senha: za6Dw9WN
TITLE:

USE OF THE AMBER LED IN RADIATION-INDUCED SKIN HYPERPIGMENTATION

KEY WORDS:

Low-Level Light Therapy; Light Emitting Diode; Skin; Hyperpigmentation; Melanosis; Oncology

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Hyperpigmentation is a dermatological condition characterized by alterations in the production or distribution of melanin by melanocytes, resulting from a variety of internal and external factors, such as exposure to ultraviolet radiation, hormonal changes, and medical treatments, including radiotherapy, which lead to skin darkening. Although it is not considered a potentially life-threatening condition nor one that causes direct harm to physical health, hyperpigmentation can significantly impact patients’ quality of life, particularly in emotional and psychological aspects. Currently, several therapeutic options are available; however, adverse effects and prolonged treatment durations often compromise adherence and may even lead to treatment discontinuation. In this context, photobiomodulation therapy (PBMT) has emerged as a promising and less invasive approach for managing hyperpigmentation. Among the light-based modalities, amber LED interacts directly with melanin, making it a potential therapeutic option. This study will be developed in two main stages. Chapter 1 presents a scoping review aimed at mapping the existing scientific literature on the use of amber LED therapy in the management of cutaneous hyperpigmentation. The search was conducted on April 10, 2025, across the following electronic databases: Cochrane Database, CINAHL, EMBASE, PubMed, and Web of Science Core Collection. Additionally, a grey literature search was performed using Google Scholar and ProQuest™ Dissertations & Theses Citation, along with a handsearch screening of the reference lists of included studies. A total of nine studies were included in the analysis. The findings demonstrated that amber LED (585–595 ± 10 nm) was primarily employed for the treatment and prevention of hyperpigmentation. In vitro studies indicated that this wavelength range can modulate pathways related to melanogenesis, cellular autophagy in melanocytes, and angiogenesis, contributing to the reduction of specific types of hyperpigmentation. Clinical trials corroborated these results, showing the efficacy of amber LED, particularly in the treatment of melasma. However, the variability of irradiation parameters and incomplete reporting of experimental data highlight the lack of standardized protocols, reinforcing the need for more robust studies and reproducible clinical guidelines for the therapeutic use of amber LED. Chapter 2 will describe a prospective observational study to be conducted at the Radiotherapy Outpatient Clinic of the Oncology Unit, University Hospital of Brasília (UNACON/HUB), as part of the Photobiomodulation Outpatient Project. Eligible participants will include patients diagnosed with breast cancer who have undergone a radical mastectomy, as well as patients with head and neck cancer undergoing radiotherapy, who are receiving amber LED therapy as part of their clinical management. The aim is to monitor and document the clinical evolution of radiationinduced hyperpigmentation in patients treated with amber LED photobiomodulation. Thus, this work seeks to consolidate scientific evidence on the use of amber LED therapy for managing hyperpigmentation through the scoping review and subsequently to generate prospective clinical data describing its therapeutic potential, with a particular focus on oncologic patients undergoing radiotherapy.

COMMITTEE MEMBERS:
Externa à Instituição - KARINA ALEXANDRA BATISTA DA SILVA FREITAS - HCFMUSP
Presidente - 3102127 - ELAINE BARROS FERREIRA
Interna - 2528668 - PAULA ELAINE DINIZ DOS REIS
Externa à Instituição - PRISCILA DE SOUZA MAGGI BONTEMPO - HUB