Banca de DEFESA: WILLKSLAINY LIMA PAIXÃO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : WILLKSLAINY LIMA PAIXÃO
DATE: 26/01/2026
TIME: 09:00
LOCAL: Microsoft Teams
TITLE:

Effect of Growth Hormone Treatment on Metabolic Outcomes in Children Born Small for Gestational Age: A Systematic Review

KEY WORDS:

Growth hormone, small for gestational age, glucose metabolism, lipid metabolism, insulin sensitivity

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

“Children born small for gestational age (SGA) are at increased risk of metabolic alterations, such as insulin resistance and dyslipidemias, which may predispose them to metabolic syndrome. Although effective in promoting growth in SGA children who do not exhibit catch-up growth, growth hormone (GH) therapy raises concerns regarding potential metabolic impacts. The aim of the present study was to systematically investigate the effects of GH treatment on metabolic outcomes in SGA children. A literature search was conducted with no restrictions on date or language in the PubMed, Web of Science, Scopus, and gray literature sources. Descriptors related to GH treatment, SGA children, and metabolic outcomes were used. Clinical trials, quasi-experimental studies, and crosssectional studies were included. Study screening and reference management were performed using the Rayyan platform. The studies showed that GH treatment increases height, weight, and growth velocity, bringing final height closer to the genetic target. Treatment was found to promote an initial increase in insulin resistance, with elevated insulin and HOMA-IR values, but without concomitant changes in blood glucose. Improvements in body composition were observed, including increased lean mass and proportional reduction in fat mass. Results regarding lipid profile and other metabolic parameters were heterogeneous and generally not clinically significant. Based on the findings of this review, GH treatment is considered safe for SGA children. The initial reduction in insulin sensitivity tends to be transient and is associated with improvements in body composition. The overall safety profile was favorable, with no evidence of significant metabolic impairment. ”

COMMITTEE MEMBERS:
Presidente - 2329402 - ANGELICA AMORIM AMATO
Externa à Instituição - ERICA CORREIA GARCIA - SESDF
Externa ao Programa - 1296742 - FLORA APARECIDA MILTON - nullExterna à Instituição - Nadyellem Graciano da Silva - SES-DF