Banca de QUALIFICAÇÃO: CAROLINA DE SOUZA CUSTODIO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : CAROLINA DE SOUZA CUSTODIO
DATE: 27/11/2025
TIME: 08:00
LOCAL: Plataforma Teams
TITLE:

Photodynamic Therapy for the Treatment of Severe Acute Radiodermatitis: An Observational Study

KEY WORDS:

Photobiomodulation therapy, Antimicrobial photodynamic therapy, Acute radiodermatitis, Ionizing radiation

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Enfermagem
SUMMARY:

ntroduction: Radiodermatitis is an inherent complication of radiotherapy, with an incidence ranging from 48% to 100%, depending on the irradiated skin area. To date, there is no reference treatment or consensus on the management of radiodermatitis, which reinforces the need to search for effective interventions. In this context, photobiomodulation emerges as a promising, minimally invasive, and well-tolerated approach. When associated with a photosensitizing agent, the technique becomes an antimicrobial Photodynamic Therapy (aPDT), capable of treating infectious conditions and biofilms, which are typical in cases of severe radiodermatitis that usually begin with moist desquamation. Objective: To describe the effect of aPDT in the treatment of severe acute radiodermatitis in patients undergoing radiotherapy. Method: This is a quantitative, descriptive, longitudinal study designed to follow approximately 30 cancer patients undergoing radiotherapy. The research will be conducted at the Photobiomodulation Outpatient Clinic, located within the Radiotherapy Outpatient Unit of the High-Complexity Care in Oncology Service of the University Hospital of Brasília (UNACON/HUB). Patients who develop severe radiodermatitis—characterized by localized or widespread moist desquamation, or ulceration associated or not with necrosis—will receive aPDT as a therapeutic approach. The protocol will employ a 660 nm wavelength laser combined with 0.1% methylene blue photosensitizer, applied every 72 hours until complete resolution of moist desquamation. Data will be analyzed using descriptive statistics. Expected Results: It is expected that the treatment will promote significant clinical improvement of the lesions resulting from severe radiodermatitis, leading to a reduction in severity grade, symptom relief (particularly pain), and acceleration of the local healing process. Based on the experiences and outcomes routinely observed in the Photobiomodulation Outpatient Clinic, it is anticipated that the healing period may be reduced to up to six treatment sessions, minimizing treatment stagnation. If well tolerated, this therapy may reduce the incidence of severe radiodermatitis cases, contributing to improved quality of oncology care and greater comfort for patients undergoing radiotherapy.

COMMITTEE MEMBERS:
Externa à Instituição - TALITA OLIVEIRA DE LIMA - HCFMUSP
Interna - 3102127 - ELAINE BARROS FERREIRA
Presidente - 2528668 - PAULA ELAINE DINIZ DOS REIS
Externa à Instituição - PRISCILA DE SOUZA MAGGI BONTEMPO - HUB